![]() An integrated proteome-wide analysis uncovers elongation and 3′-RNA processing factors as core BRD4 interactors. Notably, as an immediate consequence of acute BRD4 loss, promoter-proximal pause release is impaired, and transcriptionally engaged Pol II past this checkpoint undergoes readthrough transcription. Here, we use rapid BET protein and BRD4-selective degradation along with quantitative genome-wide approaches to investigate direct functions of BRD4 in Pol II transcription regulation. Prior research has linked BRD4 with transcription elongation. ![]() A major control point occurs during early elongation before RNA polymerase II (Pol II) is released into productive elongation. Transcription elongation has emerged as a regulatory hub in gene expression of metazoans.
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